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Simulated Lung Fluid

Simulated Lung Fluid

Simulated Lung Fluid

Respiratory tract fluid is a complex, still not well-characterized mixture containing salts, locally secreted proteins, lipids, surfactants and other compounds. Respiratory fluid is also not homogeneous and has unique regional characteristics. The simplest simulated lung fluid, called Gamble’s solution, is a physiological salt solution that has been used to study drug dissolution as well as the solubility and bioavailability of toxic compounds found in inhaled particles.

Simulated Lung Fluid 

Gamble’s solution represents the interstitial fluid deep within the lung and is used to simulate different lung conditions. It is used in pulmonary drug delivery studies as well as in studies of particles inhalation effects. Citrate is used in Gamble’s solution instead of proteins to avoid foaming and acetate instead of organic acids. Gamble’s solution has a pH of 7.4. Inquire about other simulated lung fluid formulations.

Please inquire about other simulated lung fluid formulations.

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