Lung fluid is not all the same, but you can breathe easy with a customized formula.
Lung fluid is not all the same, but you can breathe easy with a customized formula.
Simulated Lung Fluid
Respiratory tract fluid is a complex, still not well-characterized mixture containing salts, locally secreted proteins, lipids, surfactants and other compounds. Respiratory fluid is also not homogeneous and has unique regional characteristics. The simplest simulated lung fluid, called Gamble’s solution, is a physiological salt solution that has been used to study drug dissolution as well as the solubility and bioavailability of toxic compounds found in inhaled particles.
Simulated Lung Fluid
Gamble’s solution represents the interstitial fluid deep within the lung and is used to simulate different lung conditions. It is used in pulmonary drug delivery studies as well as in studies of particles inhalation effects. Citrate is used in Gamble’s solution instead of proteins to avoid foaming and acetate instead of organic acids. Gamble’s solution has a pH of 7.4. Inquire about other simulated lung fluid formulations. Please inquire about other simulated lung fluid formulations.
Simulated Lung Fluid with Surfactant
Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid and one of the main pulmonary surfactants found in lung fluid. The main function of DPPC is to reduce the surface tension of liquid in the lungs and to help adsorption of oxygen into the air-liquid interface. It is known to be a difficult process to bring DPPC into solution. With that in mind, we offer a synthetic lung fluid with DPPC dissolved and pre-mixed for your convenience.
